FOP,进行性骨化性纤维发育不良,异位骨化

天使的珊瑚

THE MEDICAL MANAGEMENT OF FIBRODYSPLASIA OSSIFICANS PROGRESSIVA: CURRENT TREATMENT CONSIDERATIONS

ICC官方指南-FOP医学管理：当前治疗的注意事项(2024版）

大会讨论热点之一是今年最新发现的控制靶点MMP-9，MMP-9的发现标志着FOP以及其他疾病导致的异位骨化，又新增了一个控制靶点，实验室数据说明此靶点对于控制异位骨化极其有效。

2024全球FOP大会-瑞典-斯德哥尔摩

卡普兰教授提到了这位同时带有 FOP 经典点位 R206 突变及 MMP-9 相关基因点突变的患者。 笔者在大会现场见到该病人，目测该病人全身主要关节活动正常，仅仅在颈背部略有一些僵 硬感，其它活动与常人无明显异常。

小文爸：2024年6月FOP 药物开发大会信息整理

International physician survey on management of FOP: a modified Delphi study

FOP管理的国际医师调研：一项修订的Delphi研究

Special considerations for clinical trials in fibrodysplasia ossificans progressiva (FOP)

FOP临床试验的特殊注意事项

Fibrodysplasia ossificans progressiva: diagnosis, management, and therapeutic horizons.

FOP：诊断、管理和治疗前景

Neofunction of ACVR1 in fibrodysplasia ossificans progressiva.

ACVR1在FOP中的新功能

创立于2018年，最早由FOP患者明明，方方，大孔等小伙伴创立，最初希望通过QQ群汇聚分散在全国各地的FOP患者，经过大家的的努力，如今，国内已经找到100多位患者和家庭。

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Molecular Developmental Biology of Fibrodysplasia Ossificans Progressiva: Measuring the Giant by Its Toe

FOP的分子发育生物学：通过脚趾去测量巨人

ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages.

ACVR1 R206H延长了人源诱导多能干细胞衍生巨噬细胞的炎症反应

Extra-articular ankylosis in fibrodysplasia ossificans progressiva.

进行性骨化纤维发育不良的关节外强直。

Fibrodysplasia ossificans progressiva: Clinical course, genetic mutations and genotype-phenotype correlations.

FOP：临床研究、基因突变与基因型-表型的关联性

Fibrodysplasia Ossificans Progressiva and Pregnancy: A Case Series and Review of the Literature.

进行性骨化性纤维发育不良与怀孕：案例系列及文献综述

 Limb swelling in patients who have fibrodysplasia ossificans progressiva.

进行性骨化性纤维发育不良患者的肢体肿胀

Preventing pressure ulcers: a systemic review.

预防压疮：系统评价

Review of the Current Management of Pressure Ulcers

现行压疮管理的综述

Fibrodysplasia ossificans progressive presenting as fibrous scalp nodules.

进行性骨化性纤维发育不良以纤维性头皮结节呈现

A viable pregnancy in a patient with myositis ossificans progressiva

患有进行性骨化性肌炎的患者的可行怀孕

Current challenges and opportunities in the care of patients with fibrodysplasia ossificans progressiva (FOP): an international, multi-stakeholder perspective

当前进行性骨化性纤维发育不良（FOP）患者护理中的挑战与机遇：来自国际多方利益相关者的视角

Fibrodysplasia ossificans progressiva. 2003

进行性骨化性纤维发育不良

The impact of fibrodysplasia ossificans progressiva (FOP) on patients and their family members: results from an international burden of illness survey

进行性骨化性纤维发育不良（FOP）对患者及其家庭成员的影响：来自国际疾病负担调查的结果

Mutation analysis and prenatal Exclusion of Fibrodysplasia Ossificans Progressiva in a Chinese fetus.

中国胎儿骨化性纤维发育不良的突变分析和产前排除。

Pregnancy in fibrodysplasia ossificans progressiva.

进行性骨化性纤维发育不良的怀孕

Surgical and Radiological Management of Complicated Uterine Leiomyoma Aided by 3D Models in a Patient with Fibrodysplasia Ossificans Progressiva

复杂子宫平滑肌瘤的外科和放射学管理，借助3D模型在进行性骨化性纤维发育不良患者中的应用

子宫平滑肌瘤的发生频率

Myositis ossificans progressiva and pregnancy.

进行性骨化性肌炎与怀孕

Dental care for patients who are unable to open their mouths.

对无法张嘴患者的牙科护理

A US population‐based study of uterine fibroid diagnosis incidence, trends, and prevalence: 2005 through 2014

美国基于人群的子宫肌瘤诊断发生率、趋势和流行率研究：2005年至2014年

Personal oral hygiene and dental caries: A systematic review of randomised controlled trials

 个人口腔卫生与龋齿：随机对照试验的系统评价

Managing Carious Lesions: Consensus Recommendations on Terminology

龋齿病变的管理：共识建议与术语

Limitations of Jaw Movement in Fibrodysplasia Ossificans Progressiva: A Review

进行性骨化性纤维发育不良的颌部运动限制：综述

Clinical trials of silver diamine fluoride in arresting caries among children: A Systematic Review.

银氟化物在儿童龋齿治疗中的临床试验：系统评价

In vitro remineralization associated with a bioerodible fluoridated resin and a fluoride varnish

与生物可腐蚀氟化树脂和氟化涂层相关的体外再矿化

Oral management in a patient with fibrodysplasia ossificans progressiva

进行性骨化性纤维发育不良患者的口腔管理

Abnormal temporomandibular joints in fibrodysplasia ossificans progressiva

进行性骨化性纤维发育不良的颞下颌关节异常

White Paper on Dental Caries Prevention and Management: A summary of the current evidence and the key issues in controlling this preventable disease

龋齿预防和管理的白皮书

Flare-Up After Maxillofacial Surgery in a Patient with Fibrodysplasia Ossificans Progressiva: An [18F]-NaF PET/CT Study and a Systematic Review

进行性骨化性纤维发育不良患者颌面外科手术后的发作：一项[18F]-NaF PET/CT研究及系统评审

Anaesthesia management of child with fibrodysplasia ossificans progressiva.

进行性骨化性纤维发育不良儿童的麻醉管理

Dental Caries: An update on dental trends and therapy.

龋齿：牙科趋势和治疗的最新进展

Evidence-based clinical practice guideline on restorative treatments for caries lesions: A report from the American Dental Association.

关于龋齿病变非修复性治疗的循证临床实践指南

Fibrodysplasia ossificans progressiva: report of a case with guidelines for pediatric dental and anesthetic management

进行性骨化性纤维发育不良：一例病例报告及儿童牙科和麻醉管理指南

Oral and dental healthcare and anesthesia for persons with fibrodysplasia ossificans progressiva.

进行性骨化性纤维发育不良患者的口腔和牙科护理及麻醉

Submandibular space swelling in a patient with fibrodysplasia ossificans progressiva: a diagnostic dilemma

进行性骨化性纤维发育不良患者的下颌下腔肿胀：一个诊断难题

氟化物涂层

Low body mass index: a risk factor for superior mesenteric artery syndrome in adolescents undergoing spinal fusion for scoliosis. 

低体重指数：在接受脊柱融合术的青少年中是上肠系膜动脉综合征的风险因素

Pulmonary and cardiac function in advanced fibrodysplasia ossificans progressiva. 

进展性纤维异位骨化症的肺功能和心脏功能

Craniofacial findings in fibrodysplasia ossificans progressiva: computerized tomography evaluation. 

进行性骨化性纤维发育不良的颅面发现：计算机断层扫描评估。口腔外科、口腔医学、口腔病理学、口腔放射学及根管治疗

Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children

神经氨酸酶抑制剂用于预防和治疗健康成人和儿童的流感

非自愿性体重减轻

Thoracic insufficiency syndrome in patients with fibrodysplasia ossificans progressiva.

进行性骨化性纤维发育不良患者的胸部功能不足综合征

Respiratory failure in disorders of the thoracic cage.

胸廓疾病引起的呼吸衰竭

Dietary reference intakes for calcium and vitamin D.

《钙和维生素D的膳食参考摄入量》

General anesthesia for dental procedures in patients with fibrodysplasia ossificans progressiva: A review of 42 cases in 30 patients.

进行性骨化性纤维发育不良患者牙科手术的全身麻醉：30名患者的42例回顾

Patients with ACVR1(R206H) mutations have an increased prevalence of cardiac conduction abnormalities on electrocardiogram in a natural history study of fibrodysplasia ossificans progressiva

ACVR1(R206H)突变患者在进行性骨化性纤维发育不良的自然历史研究中，心电图上心脏传导异常的发生率增加

The FOP connection registry: Design of an international patient-sponsored registry for Fibrodysplasia Ossificans Progressiva.

FOP连接登记处：为进行性骨化性纤维发育不良设计的国际患者赞助登记处

Spinal deformity in patients who have FOP.

进行性骨化性纤维发育不良患者的脊柱畸形

Chin-on-chest deformity in patients who have fibrodysplasia ossificans progressiva (FOP).

进行性骨化性纤维发育不良（FOP）患者的下巴贴胸畸形

Scalp nodules as a presenting sign of fibrodysplasia ossificans progressiva: a register-based study

头皮结节作为进行性骨化性纤维发育不良的首发症状: 一项基于注册的研究

Prevalence and risk factors for kidney stones in fibrodysplasia ossificans progressiva.

进行性骨化性纤维发育不良患者肾结石的流行率及风险因素

Mobility challenges and solutions for fibrodysplasia ossificans progressiva

进行性骨化性纤维发育不良患者的活动挑战与解决方案

Fibrodysplasia Ossificans Progressiva in a Four year Old Child

一名四岁儿童的进行性骨化性纤维发育不良

Rehabilitation for individuals with fibrodysplasia ossificans progressiva.

进行性骨化性纤维发育不良患者的康复治疗

The role of mast cells in functional GI disorders

肥大细胞在功能性胃肠疾病中的作用

Superior mesenteric artery syndrome in a patient with fibrodysplasia ossificans progressiva.

上肠系膜动脉综合征在一名患有进行性骨化性纤维发育不良患者中的表现

General anesthesia in fibrodysplasia ossificans progressiva: a case report and clinical review.

进行性骨化性纤维发育不良中的全身麻醉：病例报告及临床回顾

Conductive hearing loss in individuals with fibrodysplasia ossificans progressive.

进行性骨化性纤维发育不良患者的传导性听力损失

Catastrophic falls in patients who have fibrodysplasia ossificans progressiva.

FOP患者的灾难性跌倒

Severe restriction in jaw movement after route injection of local anesthetic in patients who have fibrodysplasia ossificans progressiva. 

FOP患者局部麻醉药物注射后下颌运动严重受限

Fibrodysplasia ossificans progressiva with two emergency laparotomies: A case report.

进行性骨化性纤维发育不良患者的两次紧急剖腹手术：病例报告

The diversity of the clinical phenotypes in patients with fibrodysplasia ossificans progressiva.

进行性骨化性纤维发育不良患者的临床表型多样性

Reduction of New Heterotopic Ossification (HO) in the Open‐Label, Phase 3 MOVE Trial of Palovarotene for Fibrodysplasia Ossificans Progressiva (FOP)

在开放标签3期MOVE试验中，使用Palovarotene 减少新异位骨化（HO）

Permanent heterotopic ossification at the injection site after diphtheria-tetanus-pertussis immunizations in children who have fibrodysplasia ossificans progressiva.

在进行性骨化性纤维发育不良儿童中，接种白喉-破伤风-百日咳疫苗后注射部位的永久性异位骨化

Garetosmab in fibrodysplasia ossificans progressiva: a randomized, double-blind, placebo-controlled phase 2 trial

Garetosmab 治疗进行性骨化纤维发育不良：一项随机、双盲、安慰剂对照的 2 期试验。

Palovarotene for Fibrodysplasia Ossificans Progressiva (FOP): Results of a Randomized, PlaceboControlled, Double-Blind Phase 2 Trial.

Palovarotene 治疗进行性骨化性纤维发育不良（FOP）：随机、安慰剂对照、双盲2期试验结果

Druggable targets, clinical trial design and proposed pharmacological management in fibrodysplasia ossificans progressiva.

进行性骨化性纤维发育不良中的药物靶点、临床试验设计和拟议的药理管理

Suppression of heterotopic ossification in fibrodysplasia ossificans progressiva using AAV gene delivery

通过AAV基因传递抑制进行性骨化性纤维发育不良中的异位骨化

Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva.

Saracatinib是进行性骨化性纤维发育不良的有效临床候选药物

Clearance of Senescent Cells from Injured Muscle Abrogates Heterotopic Ossification in Mouse Models of Fibrodysplasia Ossificans Progressiva.

清除受损肌肉中的衰老细胞可消除进行性骨化性纤维发育不良小鼠模型中的异位骨化

Therapeutic advances for blocking heterotopic ossification in fibrodysplasia ossificans progressiva.

阻止进行性骨化性纤维发育不良中的异位骨化的治疗进展

Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-γ agonists.

核内视黄酸受体-γ激动剂对异位骨化的强效抑制

Prophylactic treatment of rapamycin ameliorates naturally developing and episode -induced heterotopic ossification in mice expressing human mutant ACVR1.

预防性雷帕霉素治疗改善表达人类突变ACVR1的小鼠自然发生和诱导的异位骨化

Pharmacokinetics and pharmacodynamics of Garetosmab (Anti-Activin A): Results from a first-in-human phase 1 study.

Garetosmab（抗Activin A）的药代动力学和药效学：首个人体阶段I研究结果

An anti-ACVR1 antibody exacerbates heterotopic ossification by fibro-adipogenic progenitors in fibrodysplasia ossificans progressiva mice.

一种抗ACVR1抗体通过纤维-脂肪祖细胞加剧进行性骨化性纤维发育不良小鼠的异位骨化

Restoration of normal BMP signaling levels and osteogenic differentiation in FOP mesenchymal progenitor cells by mutant allele–specific targeting.

通过突变等位基因特异性靶向恢复FOP间充质前体细胞中的正常BMP信号水平和成骨分化

Derailing heterotopic ossification and RARing to go.

破坏异位骨化并RARE启动

A blocking monoclonal antibody reveals dimerization of intracellular domains of ALK2 associated with genetic disorders

一种阻断单克隆抗体揭示了与遗传疾病相关的ALK2细胞内结构域的二聚化

Application of small molecules BMP inhibitors in physiology and disease.

小分子BMP抑制剂在生理和疾病中的应用

Twenty-Ninth Annual Report of the fibrodysplasia ossificans progressiva (FOP) collaborative research project.

进行性骨化性纤维发育不良（FOP）协作研究项目第二十九届年报

Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva.

Activin-A增强mTOR信号传导以促进进行性骨化性纤维发育不良中的异常软骨发生

Gene Therapy for Fibrodysplasia Ossificans Progressiva: Feasibility and Obstacles

 进行性骨化性纤维发育不良的基因治疗：可行性和障碍

The twilight zone: benefit, risk & hope in clinical trials for FOP.

黄昏地带：进行性骨化性纤维发育不良临床试验中的利益、风险与希望

Evolving data about subtrochanteric fractures and bisphosphonates

关于转子下骨折和双膦酸盐的不断更新的数据

Effect of warfarin sodium therapy on excretion of 4-carboxy-L-glutamic acid in scleroderma, dermatomyositis, and myositis ossificans progressiva.

华法林钠治疗对硬皮病、皮肌炎和进行性骨化肌炎中4-羧基-L-谷氨酸排泄的影响

Anti-ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1

抗ACVR1抗体通过激活进行性骨化性纤维发育不良（FOP）突变的ACVR1加剧异位骨化

Rosiglitazone therapy is associated with major clinical improvements in a patient with fibrodysplasia ossificans progressiva

罗格列酮治疗与进行性骨化性纤维发育不良患者的主要临床改善相关

通过玫瑰色眼镜看待FOP

Long term use of interleukin-1 inhibitors reduce flare activity in patients with fibrodysplasia ossificans progressiva

白细胞介素-1抑制剂的长期使用减少了纤维发育不良骨化进展症患者的发作活动

Is there a biological basis for treatment of fibrodysplasia ossificans progressiva with rosiglitazone? Potential benefits and undesired effects.

使用罗格列酮治疗进行性骨化性纤维发育不良是否有生物学基础？

Treatment considerations for the management of fibrodysplasia ossificans progressiva

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